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- CRISPR Clinical Trials Ramp Up
Hi friends 👋🏼,
I spent the last few days in Park City, Utah, for a work event (some of you may remember I recently got a new job). While I haven’t yet disclosed the details of this new job, suffice it to say that I was mingling with the literal inventors of the technologies I write about here. It was a pleasure and a blessing all in one! And who knew making content here and on social media would get me there 😅
This week we’re doing the same as we always do: breaking down the science behind the diseases YOU request and providing resources to help you access emerging medical technology.
CRISPR in Clinical Trials Ramp Up
Brain Cancer Breakthrough READER REQUEST
Amyloid Plaques and Alzheimer’s READER REQUEST
Breyanzi Battles Lymphoma READER REQUEST
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✂️ CRISPR Clinical Trials Ramp Up
Since the discovery of CRISPR as a gene editing tool, the number of CRISPR-based therapies has been ramping up, resulting in a growing number of clinical trials. Here are some fast facts:
1/over 80 CRISPR-based studies are registered on clinicaltrials.gov, with nearly 35 actively recruiting patients (we’ve written about many of these here in The Cure!)
2/ 61% of all CRISPR trials target some form of cancer, followed by hematology (19%), Immunology (7%), Neurology (5%), Ophthalmology (3.5%), Infectious diseases (3.5%), and Genetics (1%).
3/ Most studies are interventional, meaning they are testing a new treatment that will “intervene” to help treat/cure a specific disease (as opposed to an observational study, where patients are merely observed to learn more about a particular condition).
4/ Most studies are in Phase 1 or 2 of clinical development. Phase 1 and 2 clinical trials focus primarily on testing safety.
🧠 Brain Cancer Breakthrough
Brain cancer is caused by the abnormal and uncontrolled growth of cells in the brain. However, pinpointing the exact causes of brain cancer is challenging; factors that may contribute include genetics, radiation exposure, age, gender, lifestyle, viruses, and other related disorders.
1/ Brain cancer is currently treated with intensive chemotherapy and radiation that can have significant adverse side effects.
Can we develop a new modality of treatment that does not rely on chemo/radiation? 👇🏼(spoiler, yes)
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